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Diabetes

Over 19 million Americans suffer with type 2-diabetes. The U.S. Centers for Disease Control and Prevention (CDC) relates that the incidence of type 2 diabetes (formerly known as adult-onset diabetes) has risen by 33 percent in the past decade and three out of every fifty American adults currently have this diet-related condition. It’s estimated that by the year 2010, some 40 percent of Americans 65 or older will have adult-onset diabetes. Complications related to diabetes are the sixth leading cause of death in the United States. Long-term outcome for those with the disease isn’t good.

People with type-2 diabetes have an average life expectancy 15 years less than those without diabetes. Heart disease and stroke account for about 65% of deaths in people with diabetes. The risk of stroke is also found to be 2 to 4 times higher in people with diabetes. Unfortunately, the news has gone from bad to worse with the FDA’s warning about the dangers of two common diabetic drugs, Avandia and Actos.

A meta-analysis which looked at four long-term trials comprising 14,291 people, found that Avandia increased risk of heart attack by 42 percent and doubled the risk of heart failure. The Actos meta-analysis looked at nineteen trials comprising more than 16,000 patients. It found that Actos lowered the risk of heart attack, stroke, and death by 18 percent, but raised risk of heart failure by forty percent. Not good.

About 1 million Americans are currently taking Avandia, which sells between $90 and $170 for a one-month supply. Its U.S. sales topped $2.2 billion last year.
Dr. David Graham, a drug safety officer with the FDA’s Office of Surveillance and Epidemiology, estimates that Avandia has caused as many as 205,000 heart attacks and strokes, some of them fatal, between 1999 and 2006. Graham’s analysis indicates that since Avandia was approved, some 80,000 patients have died from the drug’s side effects. For every month that Avandia is sold, he said, 1,600 to 2,200 patients will suffer more of these events.

GlaxoSmithKline LLC, based in London, told the agency of the risk two years ago. Yet, the FDA failed to pass along the warning to the one million Americans who already take the drug. There’s probably $2.2 billion reasons why this information wasn’t made public until this year. Only after researchers at the Cleveland Clinic forced the FDA to take notice, did the word get out to the media.

Since three quarters of all diabetics die from heart disease related conditions, doesn’t it seem strange that the drugs doctors commonly recommend for controlling diabetes actually increase the incidence of cardiovascular related deaths? I believe it does. So does Gerald Del Pan, director of the Office of Surveillance and Epidemiology, who has voiced his concerns about Avandia by stating “Cardiovascular disease being the leading cause of death of people with diabetes, having a treatment that causes that is something that doesn’t make sense to me.” It doesn’t make sense to me either. And to add fuel to the fire, recent evidence suggests thiazolidinediones are associated with an increased risk of peripheral fractures in post-menopausal women.

Other commonly used diabetic drugs known as sulfonylureas (DiaBeta, Micronase, Glynase, Diabinese, Glucatrol, Orinase, Tolinase, and Amyrel) are also associated with an increased risk of heart attack and strokes. Orinase has been shown to increase the risk for heart attack and stroke by 300 percent and increases the risk of death from all illnesses by 250 percent over those taking a sugar pill. These drugs carry a warning label, which states, “The administration of oral hypoglycemic drugs has been reported to be associated with increased risk of cardiovascular mortality as compared with treatment with diet alone or diet plus insulin. ”Insulin sensitizers or enhancing drugs including Metformin (Glucophage) and Phenformin are known as biguanides. Metformin is now the most commonly prescribed oral anti-diabetic drug in the world. It works by increasing insulin sensitivity in the liver. It also has a number of other beneficial effects, including weight loss, reduced cholesterol-triglyceride levels, and improved endothelial function.

Metformin is tolerated better than many other anti-diabetic prescription drugs. And I believe it to be the safest of the diabetes-drugs. However, it’s not without potential health risks. Those taking Metformin should be made aware that it’s associated with lactic acidosis. Lactic acidosis is a rare but serious complication that can occur due to glucophage accumulation and is fatal 50% of the time. Phenformin was pulled from the market in 1977 due to an increased risk in developing lactic acidosis, Metformin has avoided being banned by the FDA and most doctors including myself believe this medicine is the safest of the diabetic drugs. Unfortunately Metformin doesn’t slow down the ravages of diabetes, namely arteriosclerosis and increased risk of heart attack, stroke, and heart disease. I’ve discovered that my patients who follow my advice and take additional nutritional medicines along with their Metformin enjoy the best health. And even better, many of my patients are able to avoid or discontinue Metformin after following my advice below. You can read more about these life changing natural medicines by scrolling to bottom of page.

And by the way, before it was pulled from the market the warning bells rang loud and clear; Phenformin cousin of Metformin, was found to increase the risk of heart disease deaths by 300 percent. Once again like so many illnesses, once you get past the smoke and mirrors, the recommended medical “cure” is often worse than the illness. The type-2 diabetic now faces a dilemma. Do they suffer with the advances of unchecked diabetes, including risk of heart attack, stroke, and an increased risk of cardiovascular disease death? Or do they take conventional anti-diabetic drugs and increase their risk of heart attack, stroke, and death from cardiovascular disease?

What About Insulin?
What about insulin therapy you may ask? Good question. Before insulin therapy, type 1-diabetes meant a life of misery and premature death. Insulin is a life saving and therefore essential therapy for type 1 diabetes. The number of medical professionals advocating insulin therapy for type 2- diabetes continues to grow. However, its use isn’t without risk. Insulin stimulates weight gain, a known risk factor for cardiovascular disease. As patients on insulin therapy gain weight so do their requirements for increased insulin.

Please note:
The majority of patients, some ninety percent are non-insulin dependent type 2 diabetic, and suffer from poor diet, obesity, and inactivity, not from a lack of insulin. I encourage my patients with type 2- diabetes to try neutraceutical therapies instead. Certainly I recommend insulin therapy for those patients who need it but I also recommend they use the nutritional supplements below as well. Since patients who use insulin develop a tolerance for it and must use more and more over time (eventually becomes ineffective) -the goal for those using insulin should be to use the least amount as possible. Combining the appropriate nutritional medicine recommendations below along with insulin therapy helps to reduce the amount of insulin needed on a daily basis.

Neutraceuticals for Type 2-Diabetes
In the fight against type 2-diabetes there are dozens of safe and effective neutraceutical therapies. I’ll mention a few of my favorites below. Corosolic acid is found in the leaves of the banaba plant that grows in the Philippines. Subjects using a corosolic acid preparation called Glucotrim each day for two weeks experienced a 30 percent drop in blood sugar levels. Researchers considered both levels of blood sugar reduction significant. Corosolic acid may be defined as a phyto-insulin or insulin-like plant extract. And how about this for a potential side effect, subjects receiving the corosolic acid seem to show an increased tendency toward weight loss (an average weight loss of 3.2 pounds).

Gymnema sylvestre, an Indian herb used in Ayurvedic medicine, lowers the 2-hour postprandial (after meal) plasma glucose (blood sugar) concentrations, by 13 percent (207 vs. 180mg/dl).
Gymnema Sylvestre research reveals that it lowers HbA1c from 10.1% to 9.3%. This is as good if not better than common diabetic drugs. And with no side effects! Studies that show that alpha-lipoic acid (ALA) speeds the removal of glucose (sugar) from the blood of people with diabetes and that this antioxidant may prevent kidney damage associated with diabetes. And several studies suggest that treatment with ALA may help reduce pain, burning, itching, tingling, and numbness in people who have nerve damage caused by diabetes. In several studies, the mineral biotin has been shown to enhance the performance of insulin. Biotin supplements can also increase the activity of an enzyme, glucokinase, which the liver uses early in the process of utilizing blood sugar. Biotin plays a valuable role in regulating blood sugar.

Chromium is an essential mineral for human nutrition and aids in the normal function of insulin. In 12 out of 15 controlled studies of people with impaired glucose tolerance, chromium supplementation was found to improve some measure of glucose utilization or to have beneficial effects on blood lipid profiles. The type 2- diabetic dilemma – do they suffer with the advances of unchecked diabetes, including risk of heart attack, stroke, and an increased risk of cardiovascular disease death? Or do they take conventional anti-diabetic drugs and increase their risk of heart attack, stroke, and death from cardiovascular disease? – Now becomes clear. Take the right drug (Metformin or insulin), only if you need it and begin taking safe all natural nutritional therapies that have been clinically proven to help prevent and reverse diabetes.

 

My Recommendations
I recommend my patients change their diet, avoid “white foods,” walk or exercise 30-60 minutes each day, take a good multivitamin/mineral

1.Since diabetes increases the risk of cardiovascular disease, I always encourage my patients to take the Healthy Heart Multivitamin/mineral with CoQ10, L-Taurine, and Omega 3 fish oil.

2. I always recommend they begin taking the Diabetic Support Formula.
and last, but not least…

3. I suggest and many of my patients elect to take Slim N Trim. This product contains a standardized of white bean extract known as Phase 2.
It helps many of my patients lose weight, unhealthy blood fats, and reduce their blood sugar levels. Slim N Trim with Phase 2 – is a standardized extract of the white kidney bean. It promotes weight loss and improves glycemic control by reducing starch digestion. Phase 2 works in the intestine by temporarily inhibiting the activity of alpha amylase, the enzyme that breaks down starch into smaller glucose molecules. As a result, less starch is absorbed from a meal. In clinical studies, Phase 2 has been shown to lower after-meal blood sugar levels and promote loss of body fat. In two of the initial studies on Phase 2, participants were given a standardized meal containing 60 g of starch (four slices of white bread) and either a placebo or 1,500 mg of Phase 2 in a margarine spread. After the meal, participants who were given Phase 2 had an average 66-percent reduction in after-meal blood sugar levels compared to the placebo group. Participants given Phase 2 reported no adverse side effects in either study. An independent study conducted in Italy found supplementing with Phase 2 resulted in weight loss. This double blind, placebo-controlled study involved 60 overweight individuals aged 25 to 45. Participants ate starchy foods during one of their primary meals and took either a Phase 2 supplement or placebo at that time. Researchers measured body weight, body fat percentage and hip, waist and thigh circumference. By the end of the 30-day period, participants who took the Phase 2 supplement lost an average of 6.5 pounds and 10.5 percent fat mass and had significant reductions in all body measurements compared to those in the placebo group, who lost little or no weight.

You can purchase these supplements separately Here…
Diabetic Support Formula
Slim N Trim
Healthy Heart Multivitamin/mineral with CoQ10, L-Taurine, and Omega 3 fish oil


References
1.American Diabetic Association Website. www.Diabetes.org
Van Dam RM, Rimm, EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med. 2002;136:201-209.
2.Steven E. Nissen, M.D., and Kathy Wolski, M.P.H.
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. N Engl J Med356(24):2457
2471, June 14 2007.
3.Wake Forest University Baptist Medical Center (2007, July 27). Diabetes Drugs Increase Risk Of Heart Failure, Research Shows.
4.How to Prevent and Treat Diabetes with Natural Medicine, Michael Murray, N.D.
Riverhead Books, New York, NY 10014, 2003.
5.Reversing Diabetes, Julian Whitaker, M.D.
Warner Books, New York, NY 10020, 2001 PG 77 and PG 89
6.Monthly Prescribing Guide October 2007. New York, NY 10001.
References continue
1.Van Dam RM, Rimm, EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med. 2002;136:201-209.
2.Beckles GLA et al. American Diabetes Association. Diabetes Care. 1998;21(Suppl 2).
3.Colwell JA. Ann Intern Med. 1996;124(1pt2):131-135.
4.Abraira C et al. Diabetes Care. 1992;15:1560-1571.
5.Klein R et al. Am J Epidemiol. 1987;126:415-428.
6. Sheard NF. Moderate changes in weight and physical activity can prevent or delay the development of type 2 diabetes mellitus in susceptible individuals.
Nutr Rev. 2003 Feb;61(2):76–9.
7. Sedentary (N Engl J Med, 1991; 325: 147-52; Lancet, 1991; 338: 774-8; Am J Epidemiol, 1995; 41: 360-8
8. Cowie CC et al. Diabetes in America. 2nd ed.vol. 44, November ol. 44, November, References
9. How to Prevent and Treat Diabetes with Natural Medicine, Michael Murray. Riverhead Books, New York, NY 10014, 2003.
10. K. Cusi et al.Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes1.University of Texas Health Science Center (K.C., R.A.D.), San Antonio, Texas 78284; 11. Thompson KH, Orvig C, “Vanadium Compounds in the Treatment of Diabetes,” Met Ions Biol Syst. 2004;41:7:221-252..
12. Ametov AS, Barinov A, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: The Sydney trial. Diabetes Care. 2003 Mar;26(3):770–6.
13. Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review. Diabetes Technol Ther. 2006;8(6):677-687.
Udani J, Hardy M, Madsen DC. “Blocking Carbohydrate Absorption and Weight Loss: A Clinical Trial Using Phase 2 Brand Proprietary Fractionated Bean Extract.” Alt Med Rev. 2004;9(2).
14.Udani J “A Novel Method of Lowering the Glycemic Index of White Bread Using a Proprietary White Bean Extract.” Diabetes Care. 2004 Nov;27(11):2701-6.
15.Vinson JA. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal Human Subjects.” University of Scranton, September 2001.
16.Vinson JA. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind Placebo-Controlled Study with Normal College-Age Subjects.” University of Scranton, November 2001.
17.Vinson JA. “Dose Response Human Study of Amylase Inactivator with Normal Subjects Given a Full Meal.” University of Scranton, May 2002.